Disseminated histoplasmosis mimicking an acute appendicitis
- Author:
Marsilla Mariaty Marzukie
1
Author Information
1. Infectious Disease Unit, Department of Internal Medicine, Hospital Canselor Tuanku Muhriz, Pusat Perubatan Universiti Kebangsaan Malaysia
- Collective Name:Marsilla Mariaty Marzukie; Khairunisa Ahmad Affandi; Azyani Yahaya; Petrick Periyasamy
- Publication Type:Case Reports
- Keywords:
Disseminated Histoplasmosis;
Gastrointestinal Histoplasmosis;
Histoplasma capsulatum
- MeSH:
Disseminated Histoplasmosis
- From:The Malaysian Journal of Pathology
2019;41(2):223-227
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Histoplasmosis can present in a myriad of clinical manifestations, which often makes its diagnosis difficult and occasionally, deceptive. Case Report: We describe a case of a 33 years old gentleman who was clinically diagnosed as acute appendicitis at initial presentation in view of a one-week history of fever, right lower quadrant abdominal pain- and guarding at right iliac fossa. He had thrombocytopenia and lymphopenia on presentation. Mesenteric lymphadenitis and small bowel lesion were found intraoperatively, which was respectively biopsied and resected. Histopathological result confirms disseminated histoplasmosis. Retroviral screen was positive. He was treated with amphotericin B for one week, subsequently switched to oral itraconazole, followed by initiation of highly active antiretroviral therapy (HAART). Discussion: This case illustrates the various nature of histoplasmosis presentation. A high index of suspicion is needed to clinch the diagnosis and subsequently institute prompt treatment as disseminated disease can be fatal if left untreated in an immunosuppressed host.
- Full text:5.2019my1015.pdf
