Colonic adenosquamous carcinoma and mucinous adenocarcinoma with microsatellite instability
- Author:
Parra-Medina Rafael
1
,
2
,
3
,
4
Author Information
1. Department of Pathology, Fundació
2. n Universitaria de Ciencias de la Salud. Hospital Infantil de San José
3. , Bogotá
4. , Colombia
- Collective Name:Rafael Parra-Medina; Patricia Lopez-Correa; Victor Gutierrez and Fernando Polo
- Publication Type:Case Reports
- Keywords:
Adenosquamous carcinoma;
mucinous adenocarcinomas;
microsatellite instability
- MeSH:
Adenosquamous carcinoma
- From:The Malaysian Journal of Pathology
2018;40(2):199-202
- CountryMalaysia
- Language:English
-
Abstract:
A 43-year-old man presented with two-month history of fatigue, weakness, paleness, rectal bleeding, sweating, and weight loss of 10 kg in the past one month. A complete blood count revealed anaemia. The patient underwent a right hemicolectomy. The microscopic examination revealed an adenosquamous carcinoma associated with a mucinous adenocarcinoma in a patient with microsatellite instability due to loss of MLH1 and PMS2 expression and retention of MSH2 and MSH6 expression in both the squamous and glandular components. We also observed an atypical immunohistochemical phenotype in the adenocarcinoma component showing CK7 expression and reduced CK20 and CDX2 expression.
- Full text:5.2018my0968.pdf
