ALK-positive anaplastic large-cell lymphoma with primary bone involvement: A rare case and review of the literature
- Author:
Noh Byeong-Joo
1
Author Information
1. Department of Pathology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, 25440, Korea
- Collective Name:Byeong-Joo Noh; Chung Soo Han; Ji Seon Park; Juhie Lee; Youn Wha Kim and Yong-Koo Park
- Publication Type:Case Reports
- Keywords:
Anaplastic large-cell lymphoma;
primary-bone lymphoma;
ALK
- MeSH:
primary-bone lymphoma
- From:The Malaysian Journal of Pathology
2018;40(2):161-167
- CountryMalaysia
- Language:English
-
Abstract:
Primary bone lymphoma (PBL) is an uncommon type of extranodal lymphoma involvement. An anaplastic large-cell lymphoma (ALCL) is an extremely rare type of PBL, and it remains unclear whether ALCLs that primarily involve the bone exhibit favourable or unfavourable biological behaviour, and whether they are similar to ALCLs in general, or not. We reported a case of ALKpositive ALCL with primary bone involvement, and reviewed the clinicopathological features of 22 previously reported cases. An ALCL with primary bone involvement mostly affects younger patients with a preponderant towards the involvement of axial-bone. The prognosis of an ALCL that primarily involves bone is unfavourable, compared with PBL generally. The ALK-positive ALCLs in PBLs had less decedents than the ALK-negative ALCLs with a statistical non-significance (p=0.198).
- Full text:5.2018my0963.pdf
