Factors associated with mortality of oral squamous cell carcinoma (OSCC) patients managed at Hospital USM
- Author:
Muhammad Azeem Yaaqob
1
Author Information
1. School of Dental Sciences, Universiti Sains Malaysia (USM), 16150 Kubang Kerian, Malaysia
- Collective Name:Suhaily Mohd Hairon; Thirumulu Ponnuraj Kannan; Nurhayu Ab Rahman
- Publication Type:Journal Article
- Keywords:
Human papillomavirus;
mortality;
oral squamous cell carcinoma
- From:Archives of Orofacial Sciences
2019;14(1):53-63
- CountryMalaysia
- Language:English
-
Abstract:
This study was to determine the sociodemographic and clinicopathological factors that were associated
with mortality of OSCC patients managed at Hospital USM. The prevalence of high-risk human papillomavirus
(HPV) in these patients and its association with epithelial proliferation rate were also determined. A retrospective
study was conducted whereby medical records of patients diagnosed with OSCC and tissue specimens from 2005
to 2015 were studied. Formalin-fixed paraffin-embedded (FFPE) tissue specimens were evaluated for histological
grading of OSCC, p16 overexpression and Ki-67 immunostaining. Descriptive statistics, simple and multiple
logistics regressions were used for data analysis. Prognostic factors for mortality includes male gender
(AOR=10.89; 95% CI: 1.99, 59.65; p = 0.006), alcohol consumption (AOR = 16.45; 95% CI: 1.36, 59.65; p = 0.028),
not receiving treatment (AOR = 5.88; 95% CI: 1.03, 33.61; p = 0.046) and late stage (T3, T4) at presentation (AOR
= 4.85; 95% CI: 1.12, 21.02; p = 0.035). Significant association was found between high-risk HPV positivity and
higher epithelial proliferation rate expression (p < 0.003) in the OSCC tissue specimens.
- Full text:1.2019my0171.pdf
