Relationship between the epidermal growth factor receptor gene mutation and malignant pulmonary focal ground-glass lesion
10.7507/1007-4848.201610051
- VernacularTitle:表皮生长因子受体（EGFR）基因突变与肺恶性局灶性磨玻璃病变的关系
- Author:
WANG Mingdong
1
;
ZHAO Xuewei
1
Author Information
1. Department of Cardiothoracic Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, P.R.China
- Publication Type:Journal Article
- Keywords:
Epidermal growth factor receptor gene mutation;
focal ground-glass lesion;
ground-glass nodule;
lung cancer
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2017;24(9):711-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between the epidermal growth factor receptor(EGFR) gene mutation and malignant pulmonary focal ground-glass lesion (fGGL). Methods We retrospectively collected the clinical data of 86 patients with surgical treatment in the department of cardiothoracic surgery of Changzheng Hospital from August 2012 to February 2015. There were 26 males and 60 females with a mean age of 56.14±10.55 years. We analyzed the relationship between the EGFR gene mutation and the related clinical data. Results Postoperative pathology showed atypical adenomatous hyperplasia (AAH) combined with focal adenocarcinoma in situ (AIS) or AIS in 10 patients, minimally invasive adenocarcinoma (MIA) in 15, and lepidic predominant adenocarcinoma (LPA) in 61. The EGFR gene mutation reports showed the exon 19 19-del mutation in 14 patients, exon 21 L858R mutation in 27, and exon 21 L861Q mutation in 2. There was no difference between the mutation of EGFR gene and clinical factors except age and smoking (P>0.05). Till June 30, 2015, all patients were alive and follow-up was 440.48±186.61 days. Conclusion The EGFR gene in patients with malignant pulmonary fGGL shows a higher mutation rate, which provides important clinical reference data for the basic research and the clinical treatment.
