Survival analysis of stage ⅠA non-small cell lung cancer patients with lobectomy and sublobar resection
10.7507/1007-4848.201607059
- VernacularTitle:ⅠA 期非小细胞肺癌患者肺叶切除术及肺叶部分切除术的生存分析
- Author:
LIU Wenke
1
;
ZHANG Lin
1
;
ZHANG Shuguang
1
Author Information
1. Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, 110001, P.R.China
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
lobectomy;
segmentectomy;
wedge resection;
survival analysis
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2017;24(10):768-773
- CountryChina
- Language:Chinese
-
Abstract:
Objective To make a survival analysis for the stage ⅠA non-small cell lung cancer patients who underwent lobectomy, segmentectomy or wedge resection and to discuss whether the segmentectomy and wedge resection can be used as a conventional operation. Methods The clinical data of 474 patients diagnosed with ⅠA non-small cell lung cancer from January 2012 to June 2015 in the First Affiliated Hospital of China Medical University were retrospectively anlyzed. There were 192 males and 282 females with a mean age of 60 years. Their sex, age, histological type, tumor size, surgical pattern, smoking, drinking, survival rate, disease-free survival rate, recurrence rate were compared. Results Disease-free survival rate of patients with wedge resection was significantly lower than that of the patients undergoing lobectomy and segmentectomy (P<0.05). When tumor diameter≤19 mm, the disease-free survival rate of patients with wedge resection was lower than that of patients with lobectomy (P=0.006) and segmentectomy (P=0.065). Disease-free survival rate of patients with tumor diameter of 20-<30 mm was significantly lower than that of patients with tumor diameter≤19 mm (P=0.026). Excluding patients with wedge resection, disease-free survival of the patients with lobectomy and segmentectomy and tumor diameter of 20-<30 mm was significantly lower than that of patients with tumor diameter≤19 mm (P=0.036). Patients with wedge resection had significant higher risk of local recurrence than that of patients undergoing lobectomy (P<0.001) and segmentectomy (P=0.002). Conclusion StageⅠA non-small cell lung cancer patients undergoing segmentectomy can obtain approximate survival and disease-free survival rate compared with those with lobectomy, especially in patients with tumor diameter≤19 mm. Pulmonary wedge resection as surgical treatment of lung cancer patients must be selected carefully according to the actual situation and surgical purposes.
