Correlation of Twist expression in esophageal squamous cell carcinomas with clinical prognosis
10.7507/1007-4848.201608037
- VernacularTitle:Twist 在食管鳞状细胞癌中的表达与临床预后的关系
- Author:
GUO Hai
1
;
YUAN Yang
2
,
3
;
QIN Sheng
4
;
HUANG Jianming
4
;
XIAO Bo
4
;
FANG Qiang
4
;
REN Guangguo
4
Author Information
1. Department of Postgraduate, Guangxi Medical University, Nanning, 530021, P.R.China
2. Chengdu First People&rsquo
3. s Hospital, Chengdu, 630041, P.R.China
4. Department of Thoracic Surgery, Sichuan Cancer Hospital, Chengdu, 630041, P.R.China
- Publication Type:Journal Article
- Keywords:
Esophageal squamous cell carcinoma;
vascular tumor emboli;
Twist;
immunohistochemistry
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2017;24(11):849-852
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of Twist in esophageal squamous cell carcinoma (ESCC) and analyze the relationship between positive expression of Twist and disease-free survival, and to provide clinical evidence for reducing tumor recurrence, prolonging disease-free survival and improving prognosis. Methods Retrospective analysis of 70 ESCC patients receiving thoracic surgery from June 2010 to June 2012 in the Department of Thoracic Surgery, Sichuan Cancer Hospital was done, including 39 males and 31 females with an average age of 63.6 years. The expression of Twist in normal esophageal tissue, tumor tissue and vascular tumor emboli was observed by immunohistochemical staining of paraffin specimens. Results The positive rate of Twist in normal esophageal tissues was 42.9%, and in tumor tissue was 77.1% (P<0.05). The positive expression rate of Twist in tumor cells was 74.3% in patients with vascular tumor emboli and 80.0% in patients without vascular tumor emboli (P>0.05). The positive expression rate of Twist in tumor cells and in vascular tumor emboli was 74.3% and 71.4%, respectively (P>0.05). The expression of Twist in lymphatic vessels and blood vessels of patients with vascular tumor emboli was 56.0% and 72.0%, respectively (P>0.05). Conclusion Twist expression in esophageal cancer tissues is significantly higher than that in normal tissues, but there is no significant difference in the positive expression of Twist between tumor cells and the mean disease-free survival (P>0.05). At present, Twist expression can not be used as a prognostic indicator of esophageal cancer, and more researches need be further implemented.
