Effect of artificial colloid priming during cardiopulmonary bypass on the coagulation function of pediatric patients weighting less than 5 kg with congenital heart disease
10.7507/1007-4848.201811013
- VernacularTitle:体外循环中人工胶体预充对体重低于5 kg 先天性心脏病患儿术后凝血功能影响的研究
- Author:
ZHOU Chun
1
;
FENG Zhengyi
1
;
ZHAO Ju
1
;
CUI Yongli
1
;
ZHAO Mingxia
1
;
HU Jinxiao
1
;
LIU Kai
1
;
TONG Yuanyuan
1
;
LIU Jinping
1
Author Information
1. Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center of Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100037, P.R.China
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
children;
artificial colloid;
coagulation function
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2019;26(8):766-771
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of artificial colloid on coagulation function in pediatric patients weighing less than 5 kg with congenital heart disease during cardiopulmonary bypass in congenital heart disease surgery by using artificial colloid instead of human serum albumin. Methods A total of 65 pediatric patients with weight less than 5 kg who underwent congenital heart disease surgery in our hospital from September 2016 to December 2017 were included in the study. They were randomly divided into two groups: an artificial colloid group (the experimental group, n=33) and a human serum albumin combined artificial colloid group (the control group, n=32). Perioperative hemoglobin concentration (Hb), blood products and hemostatic drugs used, postoperative coagulation function index and pleural fluid volume 24 hours after surgery were monitored. Results There was no significant difference in perioperative Hb and chest tube drainage between the two groups. The platelet utilization rate in the experimental group was significantly lower than that in the control group (P<0.05). No significant difference was found in the dosage of other blood products and hemostatic drugs between the two groups during the perioperative period. There was no significant difference in coagulation parameters between the two groups before and after surgery (P>0.05). Conclusion The use of artificial colloid as colloid priming solution during cardiopulmonary bypass has no adverse effect on coagulation function in pediatric patients weighting less than 5 kg with congenital heart disease.
