Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
10.5415/apallergy.2019.9.e28
- Author:
Priscilia LIANTO
1
;
Yani ZHANG
;
Huilian CHE
Author Information
1. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, No.17 Qinghua Donglu, Haidian District, Beijing, People's Republic of China. chehuilian@cau.edu.cn
- Publication Type:Review
- Keywords:
Eosinophilic esophagitis;
Food allergy;
Pathogenesis;
Elimination diet;
Therapy
- MeSH:
Animals;
Basophils;
Cytokines;
Eosinophilic Esophagitis;
Eosinophils;
Esophagus;
Food Hypersensitivity;
Humans;
Inflammation;
Lymphocytes;
Mice;
T-Lymphocytes
- From:
Asia Pacific Allergy
2019;9(3):e28-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Eosinophilic esophagitis (EoE) is a recently recognized esophageal inflammatory disease with clinical manifestations arising from esophageal dysfunction. The etiology of EoE is currently being clarified and food allergy is evolving as the central cornerstone of EoE disease pathogenesis. Given the large number of eosinophils in the esophagus of people with EoE verified by data from murine models EoE is widely considered as the hallmark T-helper type 2 (Th2) disease of the esophagus. It is also known that some eosinophilic inflammation is controlled by other subsets of T cells such as Th9 or Th17 and control is also exerted by type 2 innate lymphoid cells acting together with basophils. In this paper we review results from molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and present in-depth molecular understanding of EoE.
