Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study
10.5415/apallergy.2019.9.e5
- Author:
Motoko MITSUI-IWAMA
1
;
Kiwako YAMAMOTO-HANADA
;
Yuma FUKUTOMI
;
Ryoji HIROTA
;
Go MUTO
;
Takeshi NAKAMURA
;
Takahiro YOSHIKAWA
;
Hiroyuki NAKAMURA
;
Masashi MIKAMI
;
Ichiro MORIOKA
;
Yukihiro OHYA
Author Information
1. Allergy Center, National Center for Child Health and Development, Tokyo, Japan. yamamoto-k@ncchd.go.jp
- Publication Type:Original Article
- Keywords:
Allergy;
Child;
Atopic dermatitis;
Paraben;
Triclosan;
Wheezing
- MeSH:
Asian Continental Ancestry Group;
Asthma;
Child;
Cross-Sectional Studies;
Dermatitis, Atopic;
Humans;
Hypersensitivity;
Limit of Detection;
Odds Ratio;
Respiratory Sounds;
Triclosan
- From:
Asia Pacific Allergy
2019;9(1):e5-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Previous studies have reported that exposure to paraben (Pb) and triclosan (TCS) is associated with allergies. However, Pb and TCS exposure in the Japanese population is not fully understood. OBJECTIVES: The present study was aimed to examine such exposure among Japanese individuals with allergic diseases. METHODS: This cross-sectional study included the International Study of Asthma and Allergies in Childhood questionnaire survey to evaluate allergic outcomes and the collection of urine samples to examine Pb and TCS exposure. RESULTS: Pb containing daily commodities was used in 84.8% children. Pb use was positively associated with current atopic dermatitis (adjusted odds ratio, 4.61; 95% confidence interval, 1.23–17.3). Urinary Pb concentrations were increased significantly in those with current atopic dermatitis (AD) (median, 4.58 vs. 0; p < 0.0001), and showed an increased tendency in those with current wheeze (median, 3.45 vs. 1.81; p = 0.0535) in participants ≤15 years old. Urinary TCS concentration was under the limit of detection in all children. CONCLUSION: Urinary levels of Pb were associated with current AD in children. We should pay more attention about Pb and TCS.
