Impact of high serum Immunoglobulin E levels on the risk of atherosclerosis in humans
10.5415/apallergy.2017.7.2.74
- Author:
Derya UNAL
1
;
Aslı GELINCIK
;
Ali ELITOK
;
Semra DEMIR
;
Müge OLGAC
;
Raif COSKUN
;
Mehmet KOCAAGA
;
Bahattin COLAKOGLU
;
Suna BUYUKOZTURK
Author Information
1. Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34015, Turkey. derya_erdogdu@hotmail.com
- Publication Type:Original Article
- Keywords:
Atherosclerosis;
Carotid Intima-media thickness;
Coronary flow reserve;
Immunglobulin E
- MeSH:
Atherosclerosis;
C-Reactive Protein;
Carotid Intima-Media Thickness;
Coronary Vessels;
Cytokines;
Echocardiography, Doppler;
Endothelin-1;
Enzyme-Linked Immunosorbent Assay;
Epidemiologic Studies;
Humans;
Immunoglobulin E;
Immunoglobulins;
Intercellular Adhesion Molecule-1;
Interleukin-6;
Myocardial Ischemia;
Pathology;
Risk Factors;
Vascular Cell Adhesion Molecule-1
- From:
Asia Pacific Allergy
2017;7(2):74-81
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Epidemiological studies show that immunoglobulin E (IgE) levels were higher in subjects with acute coronary events. However, it is unknown if the increased IgE level is a marker of future coronary incidents and whether it may be regarded as a risk factor of an ischemic heart disease. OBJECTIVE: Our aim was to investigate the relationship between IgE levels and some atherosclerotic markers in patients without known atherosclerotic disease. METHODS: Fifty patients (mean age, 40.96 ± 10.8 years) with high serum IgE levels due to various conditions who did not display evidence of an atherosclerotic disease and 30 healthy control subjects (mean age, 47 ± 8.27 years) were included in the study. Atherosclerotic disease markers including adhesion molecules like vascular cell adhesion molecule-1, intercellular adhesion molecule-1, proinflammatory cytokines such as interleukin-6, endothelin-1, and systemic inflammatory markers such as high sensitivity C-reactive protein were determined by enzyme-linked immunosorbent assay (ELISA). Endothelial functions of the coronary arteries were determined by coronary flow reserve (CFR) measurements and carotid intima media thickness using transthoracic Doppler echocardiography.
