The efficacy of single premedication with antihistamines for radiocontrast media hypersensitivity
10.5415/apallergy.2016.6.3.164
- Author:
So Hee LEE
1
;
Heung Woo PARK
;
Sang Heon CHO
;
Sun Sin KIM
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea. kimss@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Radiocontrast media;
Hypersensitivity;
Premedication
- MeSH:
Contrast Media;
Delivery of Health Care;
Histamine Antagonists;
Hypersensitivity;
Incidence;
Korea;
Observational Study;
Premedication;
Retrospective Studies;
Seoul;
Treatment Outcome
- From:
Asia Pacific Allergy
2016;6(3):164-167
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Single premedication with antihistamines for radiocontrast media (RCM) hypersensitivity is frequently used in real world at the emergent situation although its efficacy is not proven. OBJECTIVE: To evaluate the effect of intravenous antihistamines as a premedication in general population who had experience of mild adverse reactions to iodinated RCM. METHODS: A retrospective observational study on 14,785 subjects who had RCM-enhanced computed tomography scans between January 2014 and December 2015 in Seoul National University Hospital Gangnam Healthcare Center, Seoul, South Korea. RESULTS: Among 453 subjects who had a history of mild RCM-induced hypersensitivity reactions, 273 subjects had a single premedication of intravenous antihistamine. When comparing antihistamine-premedication group and nonpremedication group, there is no protective effect of antihistamines on the incidence rate and severity of hypersensitivity (10.6% vs. 11.7%, p = 0.729). CONCLUSION: The clinical efficacy of a single premedication of antihistamines for mild RCM-induced hypersensitivity was not confirmed.
