Interleukin-10 and interleukin-5 balance in patients with active asthma, those in remission, and healthy controls
10.5415/apallergy.2015.5.4.210
- Author:
Minako TOMIITA
1
;
Eduardo CAMPOS-ALBERTO
;
Masayuki SHIMA
;
Masanobu NAMIKI
;
Kazuo SUGIMOTO
;
Hiroyuki KOJIMA
;
Hiroko WATANABE
;
Kunio SEKINE
;
Toshiyuki NISHIMUTA
;
Yoichi KOHNO
;
Naoki SHIMOJO
Author Information
1. Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. shimojo@faculty.chiba-u.jp
- Publication Type:Original Article
- Keywords:
Asthma;
Child;
Interleukin-10;
Interleukin-5;
Prognosis;
Peripheral Blood Mononuclear Cell
- MeSH:
Asthma;
Child;
Cytokines;
Humans;
Inflammation;
Interleukin-10;
Interleukin-5;
Interleukins;
Mites;
Prognosis
- From:
Asia Pacific Allergy
2015;5(4):210-215
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The immunological mechanisms of asthma remission remain unclear although several reports have suggested that balance between T helper (Th) 2 cytokines and regulatory cytokines is related. OBJECTIVE: To study the balance between interleukin (IL) 10 and IL-5 in asthma clinical remission. METHODS: We measured the numbers of IL-5 and IL-10 producing cells in peripheral blood mononuclear cells stimulated with mite antigen obtained from patients with active asthma (group A, n = 18), patients in clinical remission (group R, n = 15) and nonatopic healthy controls (group H, n = 14). RESULTS: The numbers of IL-5 producing cells in groups A and R were significantly higher than in group H. The number of IL-5 producing cells was lower in group R than in group A, although the difference was not statistically significant. The number of IL-10 producing cells was higher in group R than in group A, although again the difference was not statistically significant. There was a significant difference in the number of IL-10 producing cells between groups A and H but not between groups R and H. The ratio of the number of IL-10 to IL-5 producing cells was highest in group H followed by groups R and A, and the differences were statistically significant for each pair of groups. CONCLUSION: Our study suggests that the IL-10/IL-5 balance is related to clinical asthma. The balance differs between patients in clinical remission and healthy controls, suggesting that allergic inflammation may continue even after clinical asthma remission.
