Immunoglobulin E to allergen components of house dust mite in Korean children with allergic disease
10.5415/apallergy.2015.5.3.156
- Author:
Hwan Soo KIM
1
;
Sung Hee KANG
;
Sulmui WON
;
Eu Kyoung LEE
;
Yoon Hong CHUN
;
Jong Seo YOON
;
Hyun Hee KIM
;
Jin Tack KIM
Author Information
1. Department of Pediatrics, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea. pedjsyoon@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Immunoglobulin E;
Dermatophagoides pteronyssinus antigen p 1;
Dermatophagoides pteronyssinus antigen p 2;
der p 10 protein, Dermatophagoides pteronyssinus;
Hypersensitivity, Immediate;
Child
- MeSH:
Allergens;
Asthma;
Child;
Climate;
Dermatitis, Atopic;
Dermatophagoides pteronyssinus;
Dust;
Humans;
Hypersensitivity, Immediate;
Immunoglobulin E;
Immunoglobulins;
Korea;
Prevalence;
Prospective Studies;
Pyroglyphidae;
Rhinitis, Allergic;
Urticaria
- From:
Asia Pacific Allergy
2015;5(3):156-162
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: House dust mites (HDMs) are important sources of indoor allergens. Seventeen components have been identified from Dermatophagoides pteronyssinus (Der p). OBJECTIVE: Our aim was to define the prevalence of specific IgE to components of Der p in Korea and investigate the clinical features of them in children with allergic disease. METHODS: We performed a prospective evaluation of 80 HDM sensitized patients with history of allergic rhinitis (AR), atopic dermatitis (AD), asthma and urticaria (UC). Patients underwent ImmunoCAP for total IgE, Der p, Der f, Der p 1, Der p 2, and Der p 10. RESULTS: Seventy-nine patients had detectable serum IgE to Der p, 80 patients were sensitized to Der f, 66 patients were sensitized to Der p 1, 63 patients to Der p 2, and 7 patients were sensitized to Der p 10. Der p 1 specific IgE was significantly lower in the UC group compared with the AD and AR group. Total IgE was significantly higher in the Der p 10 sensitized group. Der p 10 serum IgE level was highly correlated with crab and shrimp specific IgE. There was a significant positive correlation between total IgE and specific IgE to Der p and its components and Der f. CONCLUSION: Sensitization to HDM and its components in Korea is similar to previous studies from temperate climate. The determination of Der p 1, Der p 2, and Der p 10 specific IgE helps in obtaining additional information in regards to allergic disease.
