Repeat oral food challenges in peanut and tree nut allergic children with a history of mild/moderate reactions
10.5415/apallergy.2015.5.3.170
- Author:
Brynn Kevin WAINSTEIN
1
;
Rebecca Anne SAAD
Author Information
1. Department of Immunology and Infectious Diseases, Sydney Children's Hospital, Sydney, NSW 2031, Australia. brynn.wainstein@sesiahs.health.nsw.gov.au
- Publication Type:Original Article
- Keywords:
Peanut Hypersensitivity;
Nut Hypersensitivity;
Anaphylaxis;
Child
- MeSH:
Anaphylaxis;
Arachis;
Child;
Cohort Studies;
Follow-Up Studies;
Humans;
Hypersensitivity;
Nut Hypersensitivity;
Nuts;
Peanut Hypersensitivity;
Prospective Studies;
Skin Tests;
Trees
- From:
Asia Pacific Allergy
2015;5(3):170-176
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: In peanut and tree nut allergic children a history of anaphylaxis is associated with subsequent severe reactions. OBJECTIVE: We aimed to prospectively rechallenge peanut and tree nut allergic children with a history of mild/moderate reactions to assess their allergy over time. METHODS: In this cohort study peanut and tree nut allergic children with a history of mild/moderate reactions during a controlled oral challenge were invited to have a follow-up oral challenge to the same food at least 1 year later. RESULTS: Twenty-six children participated in the study. The mean time interval between the first and second challenge for all participants was 35.5 months. Peanut or tree nut allergy resolved in 38.5% of participants. Those with persistent peanut or tree nut allergy showed a decrease in their reaction threshold and/or increased severity in 81% of cases. There were no demographic features or skin test results that were predictive of changes in severity over time. CONCLUSION: Peanut and tree nut allergic children with a history of mild/moderate reactions who remained allergic demonstrated a high rate of more severe reactions and/or reduced thresholds upon rechallenge over a year later, however, the rate of resolution of allergy in this group may be higher than previously reported.
