Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis
10.5415/apallergy.2015.5.3.187
- Author:
Hwa Sik JUNG
1
;
Chan Ho PARK
;
Young Tae PARK
;
Mi Ae BAE
;
Youn Im LEE
;
Byung Ju KANG
;
Yangjin JEGAL
;
Jong Joon AHN
;
Taehoon LEE
Author Information
1. Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-714, Korea. ddol1996@hanmail.net
- Publication Type:Case Report
- Keywords:
Histamine H1 Antagonists;
Gynecomastia;
Anaphylaxis
- MeSH:
Anaphylaxis;
Drug-Related Side Effects and Adverse Reactions;
Gynecomastia;
Histamine H1 Antagonists;
Humans;
Male;
Omalizumab;
Young Adult
- From:
Asia Pacific Allergy
2015;5(3):187-190
- CountryRepublic of Korea
- Language:English
-
Abstract:
H1-antihistamine is generally a well-tolerated and safe drug. However, in resemblance with all other drugs, H1-antihistamines can also prompt adverse drug reactions (ADRs). We recently encountered the very unusual ADR of H1-antihistamine-induced gynecomastia. A 21-year-old man with idiopathic anaphylaxis was treated with ebastine (Ebastel), a second-generation H1-antihistamine, for the prevention of anaphylaxis. Three months later, the patient remained well without anaphylaxis, but had newly developed gynecomastia. Because anaphylaxis recurred after the cessation of H1-antihistamine, the preventive medication was changed to omalizumab. A few months later, his gynecomastia had entirely disappeared. Physicians should be aware of this exceptional ADR of H1-antihistamine.
