Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms
10.5415/apallergy.2015.5.2.59
- Author:
Ro Lan DAO
1
;
Shih Chi SU
;
Wen Hung CHUNG
Author Information
1. Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Taipei, Linkou, and Keelung, Taiwan. wenhungchung@yahoo.com
- Publication Type:Review
- Keywords:
Stevens-Johnson syndrome;
Toxic epidermal necrolysis;
Drug reaction with eosinophilia and systemic symptoms
- MeSH:
Cicatrix;
Drug Hypersensitivity Syndrome;
Incidence;
Pharmacogenetics;
Stevens-Johnson Syndrome
- From:
Asia Pacific Allergy
2015;5(2):59-67
- CountryRepublic of Korea
- Language:English
-
Abstract:
Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCAR) which are majorly caused by drugs. Though the incidence rate is low, SCAR sometimes can be life-threatening and leads to lifelong sequelae. Many pharmacogenomic associations in immune and nonimmune related genes with the development of SCAR have been discovered recently and the pharmacogenetic tests have been applied to prevent specific drug-induced SCAR. In this review, we discuss the recent advances of pharmacogenomics in SCAR.
