Clinical manifestation and sensitization of allergic children from Malaysia
10.5415/apallergy.2015.5.2.78
- Author:
Aravind YADAV
1
;
Rakesh NAIDU
Author Information
1. Department of Pediatric Pulmonary, University of Texas Health Science Center at Houston, Houston Medical School, Houston, TX 77030, USA. yadav02@yahoo.co.uk
- Publication Type:Original Article
- Keywords:
Hypersensitivity;
Allergens;
Asia;
Food;
Pyroglyphidae
- MeSH:
Allergens;
Arachis;
Asia;
Child;
Cross-Sectional Studies;
Dermatitis, Atopic;
Developing Countries;
Eggs;
Humans;
Hypersensitivity;
Immunoglobulin E;
Malaysia;
Milk;
Ovum;
Pyroglyphidae;
Triticum
- From:
Asia Pacific Allergy
2015;5(2):78-83
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: An epidemiological rise of allergic diseases in developing countries raises new challenges. Currently a paucity of data exists describing allergy symptomology and sensitization to common food and aeroallergens in young children from developing countries. OBJECTIVE: To compare changes in symptomology, food allergen sensitization and aeroallergen sensitization in a cross-sectional study of children < 2 years and 2-10 years. METHODS: A total of 192 allergic children (aged < 2 years, 35 children; aged 2-10 years, 157 children) underwent specific IgE (>0.35 kU/L) to common food (egg white, cow's milk, cod fish, wheat, peanut, soya, peanut, and shrimp) and house dust mites (Dermatophagoides pteronyssinus and Blomia tropicalis). RESULTS: In children < 2 years, atopic dermatitis (65.7%) was the most common symptom whereas in children 2-10 years it was rhinoconjunctivitis (74.5%). Higher sensitization rate to eggs (p < 0.01) and cow's milk (p = 0.044) was seen in < 2 years group when compared to the 2-10 years group, but no significant differences for shrimp (p = 0.29), wheat (p = 0.23) and soya (p = 0.057). Interestingly, sensitization to peanut (p = 0.012) and fish (p = 0.035) was significantly decreased in the 2-10 years group. Sensitization to house dust mites (p < 0.01) dramatically increased in the older children. CONCLUSION: Our study supports concept of atopic march from a developing country like Malaysia.
