Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
10.5415/apallergy.2014.4.4.253
- Author:
Ha Kyeong WON
1
;
Ji Won LEE
;
Woo Jung SONG
;
Jettanong KLAEWSONGKRAM
;
Min Gyu KANG
;
Han Ki PARK
;
Hyun Seung LEE
;
Min Hye KIM
;
Yoon Seok CHANG
;
Sang Heon CHO
;
Kyung Up MIN
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea. swj0126@gmail.com
- Publication Type:Case Report
- Keywords:
Toxic epidermal necrolysis;
Lamotrigine;
Granulysin;
Natural killer cells;
Cyclosporine
- MeSH:
Cyclosporine;
In Vitro Techniques;
Killer Cells, Natural;
Stevens-Johnson Syndrome
- From:
Asia Pacific Allergy
2014;4(4):253-256
- CountryRepublic of Korea
- Language:English
-
Abstract:
Lamotrigine is a recent medication which is prescribed for various neuropsychiatric conditions. It is generally well-tolerated, but recent pharmacoepidemiological evidence suggests that lamotrigine is associated with risks of developing severe cutaneous drug reactions like toxic epidermal necrolysis (TEN). However, there still remains the diagnostic challenge regarding how to confirm the drug causality in suspected cases. In most cases so far, lamotrigine causality has not been objectively demonstrated, which was possibly due to high risk of oral challenge tests or the lack of useful in vitro drug assays. Here we report a case of lamotrigine-induced TEN, of which the drug causality was confirmed by in vitro granulysin and cytokine assays.
