Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen
10.5415/apallergy.2014.4.3.180
- Author:
Punchama PACHARN
1
;
Nunthana SIRIPIPATTANAMONGKOL
;
Jittima VESKITKUL
;
Orathai JIRAPONGSANANURUK
;
Nualanong VISITSUNTHORN
;
Pakit VICHYANOND
Author Information
1. Division of Allergy and Immunology, Department of Pediatrics, Siriraj Hospital, Mahidol University Faculty of Medicine, Bangkok 10700, Thailand. punchama@gmail.com
- Publication Type:Case Report
- Keywords:
Immunologic desensitization;
Wheat allergy
- MeSH:
Child;
Desensitization, Immunologic;
Flour;
Humans;
Immunotherapy;
Triticum;
Wheat Hypersensitivity
- From:
Asia Pacific Allergy
2014;4(3):180-183
- CountryRepublic of Korea
- Language:English
-
Abstract:
We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of home maintenance phase. Patients could tolerate 45 g, and 60 g of wheat flour per day, respectively. We have demonstrated that OIT to a large amount of wheat in extremely sensitized patients could be achieved with a stepwise multi oral/maintenance regimen.
