Airway remodelling in asthma: role for mechanical forces
10.5415/apallergy.2014.4.1.19
- Author:
Wiparat MANUYAKORN
1
Author Information
1. Division of Pediatric Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. mwiparat@hotmail.com
- Publication Type:Review
- Keywords:
Asthma;
Airway remodelling;
Mechanical forces
- MeSH:
Adrenal Cortex Hormones;
Airway Remodeling;
Asthma;
Goblet Cells;
Hyperplasia;
Inflammation;
Muscle, Smooth;
Natural History
- From:
Asia Pacific Allergy
2014;4(1):19-24
- CountryRepublic of Korea
- Language:English
-
Abstract:
Asthma is a chronic airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness and airflow obstruction. Airway structural changes or airway remodelling consist of epithelial injury, goblet cell hyperplasia, subepithelial layer thickening, airway smooth muscle hyperplasia and angiogenesis. These changes were previously considered as a consequence of chronic airway inflammation. Even though inhaled corticosteroids can suppress airway inflammation, the natural history of asthma is still unaltered after inhaled corticosteroid treatment. As such there is increasing evidence for the role of mechanical forces within the asthmatic airway contributing to airway structural changes.
