Nuts 'n' guts: transport of food allergens across the intestinal epithelium
10.5415/apallergy.2013.3.4.257
- Author:
Dwan PRICE
1
;
Leigh ACKLAND
;
Cenk SUPHIOGLU
Author Information
1. Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, Burwood, VIC 3125, Australia.
- Publication Type:Review
- Keywords:
Food allergy;
Peanut;
Intestinal epithelial cell;
Cell tight junctions;
Cell barrier integrity;
Peyer's patch
- MeSH:
Allergens;
Arachis;
Comprehension;
Epithelial Cells;
Food Hypersensitivity;
Incidence;
Intestinal Mucosa;
Mucous Membrane;
Nuts;
Permeability;
Western World
- From:
Asia Pacific Allergy
2013;3(4):257-265
- CountryRepublic of Korea
- Language:English
-
Abstract:
The increase in the incidence of food allergy is a growing problem for the western world. This review will focus on the findings from several macromolecular epithelial transport experiments and drug permeability studies to provide a recent comprehension of food allergen intestinal epithelial cell transport and the allergen-epithelial relationship. Specifically, this review will aim to answer whether allergens can permeate the intestinal barrier directly via intestinal epithelial cells, and whether this mode of transport affects downstream immune reactions. By improving our understanding of the interactions which take place during exposure of food allergens with the intestinal epithelium, we can begin to understand whether the epithelial barrier plays a major role in the allergic sensitization process rather than simply restricting the entry of allergens to the underlying lamina propria.
