Recent applications of basophil activation tests in the diagnosis of drug hypersensitivity
10.5415/apallergy.2013.3.4.266
- Author:
Woo Jung SONG
1
;
Yoon Seok CHANG
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul 100-799, Korea. addchang@snu.ac.kr
- Publication Type:Review
- Keywords:
Drug hypersensitivity;
Immunologic tests;
Basophils;
CD63;
CD203c;
Basophil activation test
- MeSH:
Basophils;
Diagnosis;
Diagnostic Tests, Routine;
Drug Hypersensitivity;
Immunologic Tests;
In Vitro Techniques
- From:
Asia Pacific Allergy
2013;3(4):266-280
- CountryRepublic of Korea
- Language:English
-
Abstract:
Immediate-type drug hypersensitivity is an increasingly significant clinical issue; however, the diagnosis is frequently hindered due to lack of safe and precise diagnostic tests. Flow cytometry-assisted basophil activation test is a safe in vitro diagnostic tool for assessing basophil activation upon allergen stimulation. In this review, we have summarized current literature on the diagnostic utilities, new indications, and methodological aspects of the basophil activation test for the diagnosis of drug hypersensitivity.
