Staphylococcal enterotoxin specific IgE and asthma: a systematic review and meta-analysis
10.5415/apallergy.2013.3.2.120
- Author:
Woo Jung SONG
1
;
Eun Jung JO
;
Ji Won LEE
;
Hye Ryun KANG
;
Sang Heon CHO
;
Kyung Up MIN
;
Yoon Seok CHANG
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea. addchang@snu.ac.kr
- Publication Type:Meta-Analysis
- Keywords:
Asthma;
Staphylococcus;
Meta-analysis
- MeSH:
Asthma;
Case-Control Studies;
Enterotoxins;
Immunoglobulin E;
Odds Ratio;
Population Characteristics;
Prevalence;
Risk Factors;
Staphylococcus
- From:
Asia Pacific Allergy
2013;3(2):120-126
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma. OBJECTIVE: To investigate the associations between Staphylococcal enterotoxin sensitization and asthma. METHODS: A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization. RESULTS: A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82). CONCLUSION: Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.
