Recent progress of elucidating the mechanisms of drug hypersensitivity
10.5415/apallergy.2012.2.3.203
- Author:
Hideo HASHIZUME
1
Author Information
1. Department of Dermatology, Shimada Municipal Hospital, Shimada, Shizuoka 427-8502, Japan. hihashiz0001@mac.com
- Publication Type:Review
- Keywords:
Allergy;
Drug hypersensitivity;
Human herpesvirus-6;
Innate immunity;
T cell;
T cell receptor
- MeSH:
Acute Generalized Exanthematous Pustulosis;
Alarmins;
Allergy and Immunology;
Antigen-Presenting Cells;
Computer Simulation;
Drug Hypersensitivity;
Hypersensitivity;
Immunity, Innate;
Receptors, Antigen, T-Cell;
T-Lymphocyte Subsets;
T-Lymphocytes;
Th17 Cells
- From:
Asia Pacific Allergy
2012;2(3):203-209
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recent technical approaches to investigating drug hypersensitivity have provided a great deal of information to solve the mechanisms that remain poorly understood. First, immunological investigations and in silico analysis have revealed that a novel interaction between T cells and antigen-presenting cells, namely the pharmacological interaction concept, is involved in drug recognition and the hapten theory. Second, progress in immunology has provided a new concept of CD4+ T cell subsets. Th17 cells have proven to be a critical player in acute generalized exanthematous pustulosis. Our recent findings suggest that this subset might contribute to the pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis. Third, alarmins, molecules associated with innate immunity, are also associated with exaggeration and the persistence of severe drug hypersensitivity. The latest innovative techniques are providing a new landscape to examine drug hypersensitivity.
