The role of allergic risk and other factors that affect the occurrence of atopic dermatitis in the first 6 months of life
10.5415/apallergy.2011.1.2.73
- Author:
Zakiudin MUNASIR
1
;
Sudigdo SASTROASMORO
;
Samsuridjal DJAUZI
;
Sarwono WASPADJI
;
Wahyuning RAMELAN
;
Asril AMINULLAH
;
Retno WIDOWATI
;
Alida Roswita HARAHAP
;
Anang ENDARYANTO
;
Iskandar WAHIDIYAT
Author Information
1. Department of Child Health, Cipto Mangunkusumo Hospital
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
Risk factor of allergy;
IgE;
IL-5;
IFN-γ;
IL-4 genetic polymorphism
- MeSH:
Allergy and Immunology;
Asthma;
Case-Control Studies;
Cohort Studies;
Dermatitis, Atopic;
Environmental Exposure;
Enzyme-Linked Immunosorbent Assay;
Fetal Blood;
Humans;
Hypersensitivity;
Immunoglobulin E;
Immunoglobulins;
Incidence;
Infant, Newborn;
Inflammation;
Interferons;
Interleukin-5;
Life Style;
Multivariate Analysis;
Rhinitis;
Risk Factors;
Skin
- From:
Asia Pacific Allergy
2011;1(2):73-79
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammation of the skin that often appears in early childhood. The manifestation is related to the tendency towards T helper 2 cytokine immune responses (interleukin (IL)-4, IL-5). Genetic factors are suggested to play important roles in AD, and it can be transmitted to newborns, increasing their risk of developing allergies. OBJECTIVE: To determine the association between cord-blood cytokine levels (IL-5, interferon (IFN) γ), cord-blood total immunoglobulin E (IgE) level, perinatal environmental exposure, and the risks of allergy as well as the development of AD in the first 6 months of life. METHODS: A 6-month cohort study with a nested case-control within was conducted on newborns in Jakarta from December 2008 until May 2009. After the umbilical cord blood samples were taken and stored, subjects were followed up monthly until 6 months old. The occurrence of AD and lifestyle or environmental exposures were recorded. The allergic risk was determined using a modified pediatric allergy immunology work groups scoring system based on allergic history (allergic rhinitis, asthma, AD) in the family. The levels of IL-5 and IFN-γ were measured using ELISA and total IgE by CAP system FEIA. Multivariate analysis was used to evaluate risk factors. RESULTS: This study was conducted on 226 subjects. The incidence of AD was 16.4%; of those, 59% had low risk allergy, 38.5% moderate, and 2% high risk. AD mostly occurred at the age of 1 month (57%). Cord blood samples were examined in 37 subjects with AD and 51 without AD; of those, 25% showed high levels of total IgE (>1.2 IU/µL), and 51% showed normally-distributed high absorbance IL-5 values (≥0.0715, absolute value was undetected). The increased level of IL-5 was directly proportional to IgE. High absorbance IFN-γ values (≥0.0795, absolute value = 18.681 pg/µL) were observed in 52% of subjects. CONCLUSION: The associations between the risk of allergy in the family, cord-blood total IgE, IL-5, IFN levels, and some perinatal environmental exposure with AD in the first 6 months of life have not been established.
