The advances of cardiac stem cell for the treatment of cardiovascular disease
10.7507/1007-4848.201608018
- VernacularTitle:心脏干细胞治疗心血管疾病的研究进展
- Author:
LV Jingjing
1
,
2
;
SHI Guocheng
1
,
2
;
CHEN Huiwen
1
,
2
Author Information
1. Department of Cardiothoracic Surgery, Shanghai Children&rsquo
2. s Medical Center, Heart Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, P.R.China
- Publication Type:Journal Article
- Keywords:
Cardiac stem cell;
cell therapy;
cardiomyocyte regeneration;
cardiovascular disease
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2017;24(12):983-987
- CountryChina
- Language:Chinese
-
Abstract:
With the discovery of cardiac stem cell, the conception of the heart considered to be a terminally differentiated organ was changed. Cardiac stem cells possess the common characteristics of self-renew, clone formation and differentiating into cardiomyocyte, smooth muscle cell, and endothelial cell. Because of the properties of tissue specificity and lineage commitment, cardiac stem cells are considered to have great advantages over other stem cells in the treatment of cardiovascular disease. However, the low rate of engraftment still remains a problem to be solved. In recent years, people attempted to combine stem cell therapy with other ways, such as tissue engineering, gene therapy, exosome therapy, to cure cardiovascular diseases, aiming at finding better ways to treat the cardiovascular disease. This article is mainly for the reviewing of the mechanisms underlying the stem cell therapy and the combinatory use of new technology emerged these years.
