Developmental mechanism for calcific aortic valve disease
10.7507/1007-4848.201704033
- VernacularTitle:钙化性主动脉瓣疾病发病机制的研究进展
- Author:
HE Yubin
1
;
ZHU Dan
1
Author Information
1. Department of Cardiac Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, P.R.China
- Publication Type:Journal Article
- Keywords:
Aortic valve;
calcification;
inflammation;
lipid metabolism;
miRNA;
long non-coding RNAs
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2018;25(2):171-176
- CountryChina
- Language:Chinese
-
Abstract:
Calcific aortic valve disease has been the most common heart valve disorder in western world, accompanying with the increase of morbidity in our country year by year. Several molecules and mechanisms are involved in the progression of aortic valve calcification, which intensify the complexity of this pathological process. It is known that inflammation, a key factor in many diseases, has its own role in the development of aortic valve calcification. It has been demonstrated that inflammation, one of the most important participants in this disorder, which may accelerate the local lesions in aortic valve via promoting the expression of osteogenic differentiation of associated factors or decreasing the level of protective molecules. Dyslipidemia is a traditional risk factor of cardiovascular events. However, it may induce or enhance the inflammatory response whereby facilitates the calcific lesions in aortic valve. Recently, several researches have illustrated that non-coding RNAs, a stimulative factor in the progression of malignant tumor, might play a role in the development of aortic valve calcification. MiRNA and lncRNA, the non-coding RNAs which regulate the expression of genes involved in inflammatory and osteogenic differentiation, are undeniable regulators of aortic valve calcification.
