Establishment of flail chest in a rabbit model
10.7507/1007-4848.201611007
- VernacularTitle:兔连枷胸模型建立的研究
- Author:
ZHANG Yaochao
1
;
ZHANG Han
1
;
LIU Lijun
1
;
SONG Yongbin
1
;
ZHANG Guibin
1
;
CUI Hongshang
1
Author Information
1. Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, 050051, P.R.China
- Publication Type:Journal Article
- Keywords:
Flail chest;
animal model;
rabbits;
respiratory function;
pathology
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2018;25(2):159-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility of establishing a rabbit model of flail chest. Methods Flail chest model was eatablished in 12 New Zealand white rabbits after anesthesia and sterile surgery. The paradoxical movement of chest wall was recorded by the biological signal acquisition system, arterial blood was collected for blood gas analysis, the vital signs were recorded by electrocardiogram (ECG) and the lung tissue was taken for the pathological analysis at the end of the experiment. The effect of flail chest on the respiratory function of experimental animals was analyzed to evaluate the feasibility of establishing flail chest model. Results All surgeries were successful without mortality. The operation time was 41.42±7.08 min. Duration of endotracheal intubation was 79.33±12.21 min. Statistical results showed that the pH, partial pressure of arterial carbon dioxide (PaCO2) and base excess (BE) increased; while partial pressure of oxygen (PaO2) and oxygen saturation (SaO2) reduced. Pathological results showed that flail chest not intervented for a long period would lead to organic lesions. Conclusion The rabbit model of flail chest is feasible, safe, repeatable, easy and simple to handle. The animal is easy to access which is the foundation to study the disease process, recovery procedure and the efficacy after intervention.
