The status and prospect of ultrasound and microbubble-mediated gene delivery in cardiovascular disease gene therapy
10.7507/1007-4848.201612044
- VernacularTitle:超声微泡介导基因转染在心血管疾病治疗中的研究现状及展望
- Author:
QIN Xionghai
1
;
KANG Kai
1
;
SUN Lu
1
;
TIAN Hai
1
;
JIANG Shulin
1
Author Information
1. Department of Cardiovascular Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, P.R.China
- Publication Type:Journal Article
- Keywords:
Cardiovascular disease;
gene therapy;
delivery;
targeted ultrasound microbubble destruction;
ultrasound-mediated gene delivery
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2018;25(3):256-261
- CountryChina
- Language:Chinese
-
Abstract:
With the development of molecular and cellar cardiology, gene therapy to cardiovascular disease has become the hot spot and the direction of study. Now, preclinical studies on ultrasound-mediated gene delivery (UMGD) in cardiovascular disease have achieved some success, but it is still hindered by a series of practical challenges for clinical translation. Even so, UMGD still holds the promise to cardiovascular disease in gene therapy for its non-invasiveness, accuracy, safety and ability to deliver multiple genes with repeated deliveries. In this review, we will focus on the basic principle, the current development, the future prospect and drawbacks of UMGD in the therapeutic applications of cardiovascular disease.
