The value of lidocaine through different routes of administration in the treatment of tinnitus: a Meta-analysis.
- Author:
Hui LI
;
Ming LI
;
Jianning ZHANG
;
Xiangcui LI
;
Junying TAN
;
Bobo JI
- Publication Type:Journal Article
- MeSH:
Humans;
Lidocaine;
administration & dosage;
therapeutic use;
Tinnitus;
drug therapy
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2016;30(2):101-105
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the clinical value of lidocain in the treatment of tinnitus through three routes of administration (intravenous, intratympanic and acupoint injection) by analyzing literatures.
METHOD:Articles were collected through Hownet, Wanfang, VIP, Pubmed, SciVerse ScienceDirect, Springer and OVID, etc. The articles were strictly evaluated based on their quality. The Meta-analysis was performed to evaluate the outcomes by RevMan 5. 2 software.
RESULT:A total of 16 articles with 1203 patients were enrolled in the analysis. Their tinnitus history ranged from 7 hours to 20 years. Assessment methods include tinnitus loudness levels, severity scales and subjective feelings. None of articles refer to maintaining time, instead of "short-term", "short" and so on. A total of 133 cases received intravenous injection and the effective rate was 73.4% (98 cases). 50 cases and 332 cases received intratympanic and acupoint injection respectively and their effective rates were 74.0% and 87.7%, respectively. The effective rate ranged from 42.4% to 58.3% in control group. Meta-analysis results indicate that all three routes of lidocaine administrations are more effective than conventional methods (P < 0.05).
CONCLUSION:Different routes of lidocaine administration have a good but short time effects on the tinnitus control. It can effectively reduce the time of tinnitus habituation as a complementary treatment. But its value still needs further evaluation.
