Expression and clinical pathological implications of carbonic anhydrase 9 and P glycoprotein in laryngeal squamous cell carcinoma.
- Author:
Xinwei CHEN
;
Fei WANG
;
Fang XIE
;
Pin DONG
;
Xinjiang YING
- Publication Type:Journal Article
- MeSH:
ATP Binding Cassette Transporter, Subfamily B;
metabolism;
Antigens, Neoplasm;
metabolism;
Carbonic Anhydrase IX;
Carbonic Anhydrases;
metabolism;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymphatic Metastasis;
Neoplasm Grading;
Neoplasm Staging;
Polyps;
metabolism;
Vocal Cords;
metabolism;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2016;30(1):42-44
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To identify the difference of CA IX and P-gp expression level between laryngeal squamous cell carcinoma (LSCC) and benign tissues, evaluate the relationship of these two proteins in LSCC, and their correlation with clinical and pathological features.
METHOD:Immunohistochemical detection of CA IX and P-gp were performed in 47 cases of LSCC and 20 cases of vocal cord polyps.
RESULT:Overexpression of CA IX and P-gp both in LSCC and in vocal cord polyp (P < 0.05) were confirmed, with a correlation between the two proteins in LSCC (r = 0.324, P < 0.05). The expression of CA IX was related to clinical staging and lymph node metastasis in LSCC (P < 0.05). While P-gp was related to clinical staging and histological grading in LSCC (P < 0.05).
CONCLUSION:The overexpression of CA IX and P-gp may play a role in LSCC progression.
