Expression and significance of MTDH and MMP-9 in laryngeal squamous cell carcinoma.
- Author:
Yingchao CHEN
;
Wei WANG
;
Zhaolong LI
;
Jie ZHOU
;
Lan XIAO
;
Hanzhong LIU
;
Banghua LIU
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
diagnosis;
metabolism;
Case-Control Studies;
Cell Adhesion Molecules;
metabolism;
Cell Differentiation;
Head and Neck Neoplasms;
diagnosis;
metabolism;
Humans;
Laryngeal Neoplasms;
diagnosis;
metabolism;
Lymphatic Metastasis;
Matrix Metalloproteinase 9;
metabolism;
Neoplasm Staging;
Prognosis;
Squamous Cell Carcinoma of Head and Neck
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2016;30(1):60-63
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the expression changes of metadherin (MTDH) and matrix metalloproteinase-9 (MMP-9) in the laryngeal squamous cell carcinoma tissues and to investigate the significance.
METHOD:The expression of MTDH and MMP-9 in 54 cases of laryngeal squamous cell carcinoma tissues(observation group) and 30 cases of para-carcinoma tissues (control group) was examined by immunohistochemical method, the correlation between them and their correlations with the clinicopathological parameters were analyzed.
RESULT:The positive expression rates of MTDH in the observation group and control group were 64.8% (35/54) and 6.7% (2/30), respectively; the positive expression rates of MMP-9 in the observation group and control group were 70.4% (38/ 54) and 13.3% (4/30), respectively; and there was a statistically significant difference between two groups (all P < 0.01). In the laryngeal squamous cell carcinoma tissues, the expression of MTDH protein was related with degree of differentiation, lymph-node metastasis and TNM stage (all P < 0.05); and the expression of MMP-9 protein was related lymph-node metastasis and TNM stage (all P < 0.05). The expression of MTDH was positively correlated with MMP-9 in the laryngeal squamous cell carcinoma tissues (r = 0.371, P < 0.01).
CONCLUSION:The high expression of MTDH and MMP-9 was closely related to the occurrence, development and metastasis of laryngeal squamous cell carcinoma, joint detection of the two proteins was valuable for early diagnosis and prognosis of laryngeal squamous cell carcinoma.
