Association between MKK4 promoter-1304T/G polymorphism and genetic susceptibility in sporadic nasopharyngeal carcinoma.
- Author:
Mingqian LU
;
Qingzhi KONG
;
Xinhua XU
;
Hongda LU
;
Zhongxin LU
;
Kezhi SHI
;
Bingqing XU
;
Rong GUO
- Publication Type:Journal Article
- MeSH:
Carcinoma;
Genetic Predisposition to Disease;
Genotype;
Heterozygote;
Humans;
MAP Kinase Kinase 4;
genetics;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
genetics;
Polymerase Chain Reaction;
Polymorphism, Restriction Fragment Length;
Promoter Regions, Genetic
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2016;30(4):287-290
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the association between-1304T/G polymorphism in the promoter of MKK4 gene and the susceptibility in sporadic nasopharyngeal carcinoma.
METHOD:MKK4-1304T/G genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 90 NPC cases and 30 healthy controls.
RESULT:The number of nasopharyngeal carcinoma patients carrying with TG+GG genotype was much higher than those of controls (82.2% vs 66.7%, χ² =10.076, P < 0.05). Analysis showed that compared with the-1304TT genotype, -1304TG heterozygous reduced risk of nasopharyngeal carcinoma 0.56 fold (95% CI = 0.164-1.178, P < 0.01) and-1304GG lower 0.58 fold (95% CI = 0.126-1.381, P < 0.01), TG+ GG genotype variation risk of nasopharyngeal carcinoma decreased 0.72 fold (95% CI = 0.105-0.753, P < 0.01).
CONCLUSION:MKK4 gene-1304TG genotype can reduce risk of nasopharyngeal carcinoma, and it may be an independent protection factor in sporadic nasopharyngeal carcinoma.
