Efficient evaluation of standardized specific immunotherapy in personalized maintenance phase to patients of allergic rhinitis.
- Author:
Yuqin DENG
;
Yaqi YANG
;
Shenglan LI
;
Yan YAN
;
Yu XU
;
Yinghong ZHENG
;
Ailing DENG
;
Wanyi CHEN
;
Zezhang TAO
- Publication Type:Journal Article
- MeSH:
Desensitization, Immunologic;
Enzyme-Linked Immunosorbent Assay;
Humans;
Injections, Subcutaneous;
Interleukin-10;
blood;
Precision Medicine;
Quality of Life;
Rhinitis, Allergic;
drug therapy;
Surveys and Questionnaires
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2016;30(4):291-294
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the efficacy of individualized subcutaneous immunotherapy (SCIT) in allergic rhinitis(AR) maintain phase.
METHOD:Compare nasal symptom scores (VAS) and special disease scale--nasal conjunctivitis quality of life questionnaire(RQLQ) score after 3 years treatment to evaluate the therapeutic effect of each group and the level of improving patients quality of life. Take patients' blood to detect the serum level of IL-10 by enzyme linked immunosorbent test (enzyme linked immunosorbent assay).
RESULT:After 3 years treatment, there was no difference of VAS between the conventional SCIT group and the individualized SCIT group. ELISA results showed that the level of IL-10 was significantly higher in the drug symptomatic treatment group than that in the healthy group, the levels of IL-10 were significantly lower in the conventional SCIT group and the individualized SCIT group than that in the healthy group, but there was no difference between the conventional SCIT and the individualized SCIT group.
CONCLUSION:After 3 years treatment, there was no difference between conventional and individualized SCIT groups. But the efficacy of the conventional and individualized SCIT groups were significantly better than that in the drug symptomatic treatment group.
