Clinicopathological features of intraductal papillary mucinous neoplasms of the pancreas: an emphasis on predictors of malignancy.
- Author:
Won Jae YOON
1
;
Jun Kyu LEE
;
Joo Kyung PARK
;
Sang Hyub LEE
;
Ji Kon RYU
;
Yong Tae KIM
;
Yong Bum YOON
;
Jin Young JANG
;
Sun Whe KIM
;
Woo Ho KIM
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. jkryu@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Pancreas;
Neoplasms
- MeSH:
Adenoma;
Endoscopy;
Humans;
Male;
Mucins*;
Pancreas*;
Pancreatic Ducts;
Pathology;
Prognosis;
Retrospective Studies
- From:Korean Journal of Medicine
2007;72(3):272-280
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Intraductal papillary mucinous neoplasm of the pancrea (IPMN) is a newly recognized category of pancreatic exocrine tumors with a favorable prognosis. We conducted this study to evaluate clinicopathological features of IPMNs and to evaluate clinical factors associated with malignant IPMNs. METHODS: We retrospectively evaluated 91 patients (55 males, mean age 61.6 years) who were diagnosed with IPMNs with histological confirmation from 1993 to 2004. RESULTS: Fifty-eight cases were incidentally found, whereas 33 cases were symptomatic. Pathology revealed adenoma in 19 cases, IPMN with moderate dysplasia in 50 cases, noninvasive carcinoma in 8 cases, and invasive carcinoma in 14 cases. In main duct type (n=13) and combined type IPMNs (n=5), visible mucin secretion as seen on endoscopy indicated a borderline association with malignancy; a large tumor diameter (> or =30 mm) was associated with malignancy. In branch duct type IPMNs (n=73), the presence of symptoms or signs, the presence of mural nodules, a large tumor diameter (> or =27 mm) and a larger main pancreatic duct diameter (> or =4 mm) were associated with malignancy. CONCLUSIONS: In IPMNs involving the main pancreatic duct, a large tumor diameter (> or =30 mm) is associated with malignancy. In branch duct type IPMNs, the presence of symptoms or signs, the presence of mural nodules, a large tumor diameter (> or =27 mm) and a large main pancreatic duct diameter (> or =4 mm) are associated with malignancy.
