The study on clinical significance of the expression of EGFL7 in laryngeal squamous cell carcinoma.
- Author:
Shuichao GAO
1
;
Xinming YANG
;
Shisheng LI
;
Qinglai TANG
Author Information
1. Department of Otolaryngology Head and Neck Surgery, Second Xiangya Hospital of Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
blood supply;
metabolism;
pathology;
Endothelial Growth Factors;
genetics;
metabolism;
Female;
Humans;
Laryngeal Neoplasms;
blood supply;
metabolism;
pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Neoplasm Staging
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(3):147-150
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the association and mechanism of EGFL7 expression level with the invasion and metastasis of laryngeal squamous cell carcinoma.
METHOD:RT-PCR and Western blotting were used respectively to detect the level of EGFL7 mRNA and protein form 33 fresh laryngeal carcinoma tissues and matched para-neoplastic non-tumor tissues. The immunohistochemistry technique was performed to determine microvessel density (MVD) in 33 tumor tissues. The association of EGFL7 expression and MVD with clinicopathological characteristics was analyzed.
RESULT:EGFL7 mRNA and protein expression were both significantly higher in the tumor tissues than in the paraneoplastic non-tumor tissues (P < 0.01). Furthermore, the expression of EGFL7 mRNA was highly correlated with the expression of EGFL7 protein (r = 0.786, P < 0.01). EGFL7 expression and MVD were highly correlated with clinical stage, tumor size and the presence of lymph node metastasis (P < 0.05), but was not correlated with the patients gender, age, tumor sit and tumor site differentiation (P > 0.05).
CONCLUSION:EGFL7 may have a close correlation with the development of laryngeal carcinoma via its impact on tubulogenesis and vessel shape. EGFL7 might serve as a tumor marker for assessing the progression of laryngeal carcinoma and a guide of clinical therapeutic decisions.
