The expression of NOD1 and NOD2 and the regulation of glucocorticoids on them in allergic rhinitis.
- Author:
Shuang HU
1
;
Xuejun YOU
;
Pingping CAO
;
Zheng LIU
;
Yonghua CUI
Author Information
1. Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430030,China.
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Female;
Gene Expression Regulation;
Glucocorticoids;
pharmacology;
Humans;
Male;
Middle Aged;
Nasal Mucosa;
drug effects;
metabolism;
Nod1 Signaling Adaptor Protein;
metabolism;
Nod2 Signaling Adaptor Protein;
metabolism;
Rhinitis, Allergic;
Rhinitis, Allergic, Perennial;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(8):393-396
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of NOD1 and NOD2 in the nasal mucosa of healthy individuals and allergic rhinitis(AR), and explored the regulation of glucocorticoids on them.
METHOD:RT-PCR and immunohistochemistry were used to detect the expression of NOD1 and NOD2 in nasal mucosa from healthy control and AR. Nasal explant culture was used to explore the effect of glucocorticoids on NOD1 and NOD2 expression.
RESULT:NOD1 and NOD2 mRNA expression level was significantly increased in AR compared with control. Immunohistochemical staining demonstrated that NOD1 and NOD2 were mainly expressed by epithelial cells and some unknown cells in lamina propria and there were significantly more positive staining cells were observed in AR tissue when compared with control. Glucocorticoids down-regulated NOD1 and NOD2 expression in AR.
CONCLUSION:NOD1 and NOD2 as two PRRs may take part in the pathogenesis of AR, glucocorticoids may play a therapeutical role on allergic rhinitis through down-regulated the expression of NOD1 and NOD2.
