The serum level transformation of IFN-gamma, IL-4 and IgE before and after SIT in patients with allergic rhinitis.
- Author:
Yujin LI
1
;
Peizhong LI
Author Information
1. Department of Otorhinolaryngology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, 223300, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Desensitization, Immunologic;
Female;
Humans;
Immunoglobulin E;
blood;
Interferon-gamma;
blood;
Interleukin-4;
blood;
Male;
Middle Aged;
Rhinitis, Allergic;
Rhinitis, Allergic, Perennial;
blood;
immunology;
therapy;
Serum;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(8):397-403
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the efficacy and the transformation of IFN-gamma, IL-4, total IgE and specific IgE before and after specific immune therapy(SIT) in patients with allergic rhinitis.
METHOD:The subjective symptom and levels of IFN-gamma, IL-4, total IgE and specific IgE were observed in 40 patients with allergic rhinitis before and after SIT.
RESULT:Total effective rate in patients after SIT was 85%. There's no significant difference between the levels of specific IgE before and after SIT(P>0.05) ,while the levels of IL-4 and total IgE were significantly lower, the levels of IFN-gamma were significantly higher pre than that of post SIT.
CONCLUSION:SIT is safe and effective,and can regulate the levels of IFN-gamma, IgE and IL-4. But the role of specific IgE in SIT is still unknown.
