Expression of EGFR about different region tissues and its relationship with histological differentiation in laryngeal carcinoma.
10.13201/j.issn.1001-1781.2012.03.008
- Author:
Shiwen ZHANG
1
;
Xiaoguang HE
;
Xiaojiang LI
;
Yuanling WANG
Author Information
1. Department of Head and Neck, the Third Affiliated Hospital of Kunming Medical College, Kunming, 650118, China.
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
metabolism;
pathology;
Cell Differentiation;
ErbB Receptors;
metabolism;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(3):123-128
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expression of EGFR in different region of laryngeal tissue, and use quantitive analysis to discuss the relation between expression of EGFR and histological differentiation.
METHOD:Collected 36 cases of laryngeal tissue example, which be divided in to three groups based on pathobiology. Using Western Blot to detect the EGFR expression in cancer tissue, para cancer tissue and normal tissue, and combined imaging analytical technique to analyse the relation between expression of EGFR and histological differentiation.
RESULT:In same region of cancer tissue the expression of EGFR is different along with different tissue differentiation (P<0.05), but in normal tissue this different is not existing (P>0.05). In same tissue differentiation the expression of EGFR is different in cancer tissue, para cancer tissue and normal tissue (P<0.05).
CONCLUSION:EGFR highly express in laryngeal cancer tissue, and relate with the tissue differentiation of laryngeal cancer. EGFR is an important indicator to study the emerging and progression of laryngeal cancer.
