Outcome in patients with acute low-tone sensorineural hearing loss by administration of different doses of glucocorticoids.
- Author:
Lian HUI
1
;
Gang YU
;
Ning YANG
;
Xuejun JIANG
Author Information
1. Department of Otolaryngology, First Affiliated Hospital of China Medical University, Shenyang 110001, China. huilian613@126.com
- Publication Type:Journal Article
- MeSH:
Adult;
Female;
Glucocorticoids;
administration & dosage;
therapeutic use;
Hearing Loss, Sensorineural;
drug therapy;
Humans;
Male;
Middle Aged;
Prednisone;
administration & dosage;
therapeutic use;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(1):19-21
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Aimed to compare the outcome in patients with acute low-tone sensorineural hearing loss (ALHL) treated with different doses of glucocorticoids.
METHOD:Fifty-four ALHL patients were randomly divided into no-prednisone group (n = ten), low-dose prednisone group (n = 22) and high-dose prednisone group (n = 22). All patients were treated for ten days and followed up for six months from the initial examination.
RESULT:The cure rates(complete recovery)were 30.0%, 59.1%, 90.9% respectively and the improved rates (complete recovery and partial recovery) were 40.0%, 86.4%, 95.5% respectively in the three groups of no prednisone group, low-dose prednisone group and high-dose prednisone group. The low-dose prednisone group therapy for ALHL showed significant improved rates than the no prednisone group (P < 0.05). The high-dose prednisone group therapy for ALHL showed significant cure rates than the low-dose prednisone group (P < 0.05).
CONCLUSION:High-dose glucocorticoids is more effective than low dose. It is suggested that the etiology of ALHL is related with both an endolymphatic hydrops and an autoimmunological mechanism.
