The association between genetic polymorphisms of IL-6 and the susceptibility of chronic rhinosinusitis.
10.13201/j.issn.1001-1781.2012.05.006
- Author:
Meili ZHANG
1
;
Peihua NI
;
Changping CAI
;
Nijun CHEN
;
Shili WANG
Author Information
1. Department of Otorhinolaryngology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Case-Control Studies;
China;
Chronic Disease;
Female;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Humans;
Interleukin-6;
genetics;
Male;
Middle Aged;
Polymorphism, Single Nucleotide;
Risk Factors;
Sinusitis;
genetics;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(5):197-204
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between the promoter polymorphism of IL6 (-174G > C, -572G > C and -597G > A) and chronic rhinosinusitis (CRS).
METHOD:The case-control study consisted of 123 patients with CRS and 239 controls from a Chinese Han population from Shanghai. The genotypes of the subjects were determined by polymerase chain reaction-restriction fragment length polymorphism and gene sequencing. Besides, the concentrations of the totle immunoglobulin E (TIgE) and eosinophilic cationic protein (ECP) in the blood were also determined.
RESULT:The -174G > C and -597G > A polymorphisms were not detected in this study population. Significant differences in genotype and allele frequencies of -572C/G were observed between CRS patients and control groups. In CRS patients, the CC, CG, GG genotype frequencies were 69.1%, 29.3%, 1.6%, C, G allele frequencies were 83.7%, 16.3%. In control group, the genotype frequencies were 55.2%, 42.3%, 2.5%, the allele frequencies were 76.4%, 23.6%, respectively. The -572CC genotype was associated with an increased risk of developing CRS (P < 0.05, OR = 1.932, 95% CI, 1.205-3.097). There was no significant differences in the concentrations of the TIgE and ECP among each genotype.
CONCLUSION:IL-6 gene -572G > C polymorphism is associated with the susceptibility to CRS. CC genotype could be an independent risk factor.
