To study of the nasal mucosa remodeling of allergic rhinitis patients.
10.13201/j.issn.1001-1781.2012.05.008
- Author:
Huijie FENG
1
;
Yang YANG
;
Huan ZHOU
;
Sujuan BAI
Author Information
1. Department of Otorhinolaryngology, People's Hospital of Shanghai Putuo District, Shanghai 200060, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Case-Control Studies;
Female;
Humans;
Male;
Matrix Metalloproteinase 9;
metabolism;
Middle Aged;
Nasal Mucosa;
metabolism;
pathology;
Rhinitis, Allergic, Perennial;
metabolism;
pathology;
Tissue Inhibitor of Metalloproteinase-1;
metabolism;
Transforming Growth Factor beta1;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(5):205-208
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore whether there was tissue remodeling in the nasal mucosa of allergic rhinitis (AR) patients and detect the protein expressions of transforming growth factor beta1 (TGF-beta1), matrix metalloproteinases 9 (MMP-9) and tissue inhibitors of matrix metalloproteinases 1 (TIMP-1) in the nasal mucosa of these patients.
METHOD:Pathologic staining was used to explore the mucosa of the middle turbinate tissues from 16 patients with mild AR, from 12 patients with severe AR, and from 15 non-AR, respect. The infiltrating of eosinophils and damage of epithelium were examined by the hematoxylin-eosin staining; goblet cells were counted by the alcian blue-periodic acid-schiff staining; the percentage area of extracellular matrix was determined by the MT; the protein expressions were measured by ELISA of TGF-beta1, MMP-9 and TIMP-1 in the middle turbinate tissues.
RESULT:Compared with the control group, significant eosinophil infiltration and goblet cells were observed in both AR groups (P < 0.05). Evident epithelial damage and extracellular matrix deposition were observed in severe-AR group (P < 0.05). The expressions of TGF-beta1, MMP-9 and TIMP-1 in AR tissues were significant increased (P < 0.05).
CONCLUSION:The nasal mucosa remodeling was observed in AR groups. The characteristics were as follows: eosinophils infiltration, epithelial damage, goblet cells hyperplasia and extracellular matrix deposition. TGF-beta1, MMP-9, TIMP-1 may play a role in the tissue remodeling processes.
