Significance expression and relationships with endothelin-1, matrix metalloproteinase-9 in the laryngeal carcinoma.
- Author:
Yan LIN
1
;
Jingjing ZHANG
;
Shixi LIU
;
Feng LIU
;
Jian ZOU
;
Mingxiu ZHENG
Author Information
1. Department of Otorhinolaryngology, the Second Affiliated.Hospital of Kunming Medical College, Kunming, 650101, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Endothelin-1;
metabolism;
Female;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Matrix Metalloproteinase 9;
metabolism;
Middle Aged;
Neoplasm Staging
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(6):245-251
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the expression of endothelin-1(ET-1) and matrix metalloproteinase-9 (MMP-9) in laryngeal carcinoma and their correlations with clinical features.
METHOD:The expression of ET-1 and MMP-9 was detected by immunohistochemical method in 58 specimens of laryngeal carcinoma, 28 specimens of polyps of vocal cord and 19 specimens of normal laryngeal tissues.
RESULT:The expressions of ET-1, MMP-9 in laryngeal carcinoma were remarkably higher,compared to polyps of vocal cord and normal laryngeal tissues (P < 0.05). The expression of ET-1, MMP-9 was associated with clinical stage, T stage and lymph node metastasis. Expression levels of ET-land MMP-9 correlated significantly with each other (r(s) = 0.693, P < 0.05).
CONCLUSION:The expression of ET-1 and MMP-9 may be the vital indexes in laryngeal carcinoma.
