The expression of IL-9, IL-17 and Foxp3 in nasal polyps.
- Author:
Xiaoping PU
;
Yongming MA
;
Wei ZHU
;
Yue WANG
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Female;
Forkhead Transcription Factors;
metabolism;
Humans;
Interleukin-17;
metabolism;
Interleukin-9;
metabolism;
Male;
Middle Aged;
Nasal Polyps;
metabolism;
T-Lymphocytes, Regulatory;
cytology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(8):513-519
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the expression of IL-9, IL-17 and Foxp3 in nasal polyps,so that to explore the role of Th9, Th17/Treg cells imbalance in pathogenesis of nasal polyposis.
METHOD:Forty cases of nasal polyps and 20 cases of normal middle turbinate mucosa (controls) were involved in this study. The expression patterns of IL-9, IL-17 and Foxp3 were detected by immunohistochemistry.
RESULT:The positive rates of IL-9 and IL-17 in nasal polyps tissues were respectively 75.0% and 80.0%, which were both significantly higher than those in the controls (positive rates were 35.0% and 50.0%, respectively), but the Foxp3 expression was downregulated in nasal polyps tissues (37.5%) compared to the controls (80.0%), P < 0.05 respectively.
CONCLUSION:The cytokines IL-9 and IL-17 are obviously involved in the occurrence and development of nasal polyposis, suggesting remarkable infiltration of Th9 and Th17/Treg imbalance exist in nasal polyps, both of which may play important roles in pathogenesis of nasal polyposis.
