Change of auditory brainstem response in hearing deprivation rat model induced by bilateral cochlears ablation.
- Author:
Haixia HAN
;
Ou XU
;
Heyin HUANG
;
Yuxing WANG
;
Hong LU
- Publication Type:Journal Article
- MeSH:
Animals;
Auditory Threshold;
Cochlea;
physiopathology;
surgery;
Disease Models, Animal;
Evoked Potentials, Auditory, Brain Stem;
physiology;
Hearing Loss;
Male;
Rats;
Rats, Sprague-Dawley
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(7):465-467
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the change of auditory brainstem response (ABR) in hearing deprivation rat model induced by bilateral cochlears ablation at different time points.
METHOD:Forty SD rats were randomly divided into four experiment groups including 2-week group, 4-week group, 6-week group, 8-week group and four control groups with 5 rats (n = 10) in each group. Then bilateral cochlears ablation was applied to experiment groups. The threshold value of ABR was measured at different time and latent period of each wave was compared.
RESULT:The threshold of ABR in experiment group was elevated significantly. The latent period of each wave was pro longed significantly (P < 0.01). In experiment group, the threshold value of ABR in 2-week and 4-week group was significantly greater than that in 6-week group and 8-week group (P < 0.01).
CONCLUSION:Bilateral cochlears ablation surgery could elevate the threshold of ABR and latent period of each wave prolonged. The effect of hearing deprivation became apparent after surgery for 4 weeks.
