Expression and significance of gene Rad52 in nasopharyngeal carcinoma.
- Author:
Lili WEI
;
Xiaoli YANG
;
Huixin MING
;
Ping LI
- Publication Type:Journal Article
- MeSH:
Adult;
Carcinoma;
Female;
Gene Expression Regulation, Neoplastic;
Humans;
Male;
Middle Aged;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
metabolism;
Neoplasm Staging;
Rad52 DNA Repair and Recombination Protein;
metabolism;
Survival Rate;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(7):486-489
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression and clinical significance of Rad52, a homologous recombination repair gene, in tissues of nasopharyngeal carcinoma (NPC).
METHOD:The expression of Rad52 was detected with three-step immunohistochemistry technique in tissues of 38 NPC patients and which have the corresponding paracancerous tissues. All of the Rad52 expression and clinical data (gender, age, clinical stage ) were compared and analyzed to conclude the relationship between them.
RESULT:The Rad52 expressions were significantly different from NPC tissues to peri-NPC tissues (P < 0.05). It was found by Spearman analysis method that the Rad52 expression decreased with patients'clinical stages (P < 0.05), but has no significant relationship with gender, age, recurrence, and lymphonode metastasis (P > 0.05). The expression of Rad52 influenced the survival time of NPC patients significantly (P < 0.05).
CONCLUSION:The Rad52 expression can be a useful prognostic and treatment factor for NPC patients.
