The expression of ubiquitin in laryngeal squamous cell carcinoma with lymph node metastasis and its clinical significance.
- Author:
Gengming CAI
1
;
Gangcai ZHU
2
;
Yong LIU
2
;
Changyun YU
2
;
Haolei TAN
2
;
Yuanzheng QIU
2
;
Xin ZHANG
2
;
Donghai HUANG
2
Author Information
1. Department of Otolaryngoloy, the First Hospital of Quanzhou, Fujian Medical University, Quanzhou, 362000, China.
2. Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central South University.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Head and Neck Neoplasms;
metabolism;
pathology;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymph Nodes;
pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Squamous Cell Carcinoma of Head and Neck;
Ubiquitin;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(17):944-947
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the ubiquitin expression in laryngeal squamous cell carcinoma (LSCC) whether along with local lymph node metastasis, and further study its correlation with local lymph node metastasis and other clinicopathological parameters in laryngeal squamous cell carcinoma.
METHOD:We detected the different expression level of ubiquitin in paraffin specimens between 19 cases of LSCC associated with cervical lymph node metastasis LSCC(N+) and 20 cases of LSCC not associated with cervical lymph node metastasis LSCC(N-) by immunohistochemical staining combined with stereology image analysis system. Statistics were analyzed by student test, variance analysis and ROC curve.
RESULT:Ubiquitin expression in LSCC(N+) was significantly higher than LSCC(N-) (P < 0.01); their expression level was not correlated with age,history of tobacco, alcohol addiction, clinical stage and primary site,etc.
CONCLUSION:Ubiquitin was significantly up-expressed in LSCC(N+) than ILSCC (N-), which may imply that it is one of the important elements in mechanism of lymph node metastasis in LSCC.
