Study on laryngeal cancer related on polymorphism of the Arg399Gln of XRCC1 DNA repair gene in different nationalities in Xinjiang.
- Author:
Qukuerhan AYIHENG
1
;
A'ersilan BOGELA
2
Author Information
1. Department of Otolaryngology, the First Hospital of Xinjiang Medical University, Urumqi, 830054, China. ayhen979@sina.com
2. Department of Otolaryngology, the First Hospital of Xinjiang Medical University, Urumqi, 830054, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Case-Control Studies;
China;
epidemiology;
DNA Repair;
DNA-Binding Proteins;
genetics;
Ethnic Groups;
genetics;
Female;
Humans;
Laryngeal Neoplasms;
epidemiology;
genetics;
Male;
Middle Aged;
Polymorphism, Single Nucleotide;
X-ray Repair Cross Complementing Protein 1
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(17):948-954
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study genetic polymorphism of XRCC1 Arg399Gln and the laryngeal cancer risk.
METHOD:A case-control study was performed on 60 patients with laryngeal squamous cell carcinoma and 120 random healthy control group. The two groups were matched by sex and age. Multiplex SNaPshot technic was used to explore polymorphism of DNA repair gene XRCC1 Arg399Gln in distribution of patient with laryngeal squamous cell carcinoma and normal control.
RESULT:The frequency of XRCC1c. 399Arg/Gln+Gln/Gln genotypes in the case group was higher than that in the control group (P < 0.05). The expression of the three nations (chinese, uyhur, kazak) was Respectively a 1.47, 1.32, 0.77 fold increased risk of laryngeal cancer for individuals arrying XRCC1c. 399Arg/Gln+Gln/Gln genotypes (OR = 1.47, 95% CI = 0.46-4.69), compared with subjects carryin Arg/Arg genotype.
CONCLUSION:The polymorphism of XRCC1Arg399GIn might be associated with the susceptibility of laryngeal cancer. The mutation of XRCC1c. 399 Arg-->Gln might lead to a increased risk of laryngeal cancer.
