Changes of serum aminotransferase in children with obstructive sleep apnea hypopnea syndrome.
- Author:
Zhenjiang CHEN
1
;
Likun DUO
2
Author Information
1. Department of Pediatrics, the Affiliated Jinxiang Hospital of Jining Medical College, Jining, 272200, China.
2. Department of Pediatrics, the First Affiliated Hospital of Xinjiang Medical University.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Blood Glucose;
analysis;
Body Mass Index;
Case-Control Studies;
Child;
Fatty Liver;
blood;
enzymology;
Female;
Humans;
Insulin;
blood;
Male;
Obesity;
blood;
complications;
Risk Factors;
Sleep Apnea, Obstructive;
blood;
complications;
Snoring;
blood;
Transaminases;
blood
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2013;27(15):809-812
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Obstructive sleep apnea hypopnea syndrome (OSAHS) and non-alcoholic fatty liver disease (NAFLD) are both strongly associated with obesity. Whether OSAHS is an independent risk factor for liver injury or not is uncertain. To assess the hypothesis that OSAHS is associated with liver injury independent of obesity.
METHOD:One hundred and thirty children with OSAHS and 77 children with primary snoring(PS) were enrolled. Polysomnography was performed. Body mass index (BMI), liver function tests, serum lipids, fasting plasma glucose (FPG), and insulin (INS) were measured.
RESULT:Seventeen children of OSAHS had elevated serum aminotransferase levels,while only 2 children of non-OSAHS had elevated serum aminotransferase in healthy control group (chi2 = 5.18, P < 0.05; OR = 5.64 CI 1.27-24.97). Fifteen children of obese had elevated serum aminotransferase levels, while only 4 children had elevated serum aminotransferase in non-obese group (chi2 = 4.58, P < 0.05; (OR = 1.97 CI 1.06-3.67). Seventy cases of obese children, 15 cases of elevated aminotransferase levels (21.4%), namely fatty liver patients, of these children, 14 had OSAHS (93.3%). In contrast, OSAHS was present in only 67.3% of obese children without elevated aminotransferase.
CONCLUSION:OSAHS may be a risk factor for liver injury independent of obesity; Increased liver enzyme levels are frequently found in obese snoring children, particularly among those with OSAHS.
